Van de Ven Double Ends The Toffees' Run at New Stadium
The Dutch defender became the first backline player to net two goals in a English top-flight game for Spurs since the Belgian defender in spring 2013.
Match summary
The Spurs defender heads into the net twice in opening period
The home side's defender has goal disallowed after video check
Pape Matar Sarr scores third in dying moments
The defeat is Everton's initial at Hill Dickinson Stadium
Micky van de Ven found the net twice as Tottenham prolonged their winning streak on the road in the Premier League and delivered Everton their initial loss at their new home.
Everton were undefeated in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having left their historic home behind after 133 years at the end of the previous campaign.
But Spurs captain the Dutchman pounced on two occasions from set-pieces in the opening 45 minutes to place their impressive record at jeopardy, and they were failed to turn it around before the midfielder - assisted by ex-Everton forward Richarlison - headed home a final goal to put the game to bed.
The Everton defender believed he had levelled the scores five minutes after the defender's opener, directing a powerful header past Guglielmo Vicario from an set-piece.
Beto, in the meantime, missed a handful of chances, while Vicario made a succession of fine stops to guarantee the London club went five matches on the road unbeaten in the Premier League.
But the VAR stepped in, instructing the match official to review the score on the pitchside monitor and the referee decided that the winger and Iliman Ndiaye were in offside positions and had interfered with the Tottenham goalkeeper.
This victory moves the manager's side up to third in the Premier League, a handful of points off north London rivals and table-toppers the Gunners.
The Merseyside club remain in 14th position and sit half a dozen points ahead of the relegation zone.
Tottenham analysis: Van de Ven excels in role at both ends of pitch
Following a uninspiring weekday display in the European competition against Monaco, where they managed a mere two shots on goal, the manager chose the French striker up front instead of ex-Everton forward Richarlison.
The new arrival was unable to make much of an impact before being substituted for Richarlison after an hour on the field, but it emerged he proved unnecessary in the end.
Defender the Dutchman transformed into an attacking force to be feared.
Tottenham's opening strike came from a well-worked set-piece play, with the midfielder directing the ball back across the six-yard box for an free the defender to head home.
And Ven de Ven - stepping up as captain in the Argentine's unavailability - added his next goal in first-half stoppage time as he outjumped Jordan Pickford to nod in.
The Dutchman was equally impressive in defensive duties, partnering effectively with Kevin Danso as the duo handled excellently with the numerous deliveries thrown their way by Everton.
Toffees breakdown: Toffees missing striker's instinct
Everton's recent stadium had been a happy hunting ground, but it seems the freshness may have faded somewhat and fans flocked to the exits after Sarr's third for Spurs.
The end in the team's winning streak at home will not be a massive concern for the manager, but their attacking woes are.
Beto and Thierno Barry - the Everton's pair of established centre-forwards - had scored just a single goal between them before Sunday's outing.
And they were unable to contribute to that poor record on a wet and gloomy evening on in Liverpool.
The striker's form was epitomized when he opted to bicycle-kick a golden opportunity from near the goal, even with having space and opportunity to reposition for a more conventional shot that would have tested the keeper.
Barry, as well, was unable to influence the game after replacing the starter in the 65th minute.
It was not for a shortage of opportunity. The majority of the home side's attacks came through Grealish and the forward, who relentlessly whipped dangerous crosses into the Tottenham box.
Upcoming fixtures for these two sides?
The Toffees: The team travel to Sunderland in the top flight on Monday, 3 November at 8 PM.
Tottenham: The London club travel to St James' Park on late October for their fourth-round League Cup tie against the Magpies.